منابع مشابه
Genetic aspects of pheochromocytoma.
Pheochromocytomas are derived from chromaffin cells of the adrenal medulla which synthesize and secrete catecholamines, thus affecting the cardiovascular system and metabolic processes. Pheochromocytoma is a tumor of the following multicarcinoma hereditary syndromes: type 2 multiple endocrine neoplasia, von Hippel-Lindau disease, type 1 neurofibromatosis and the pheochromocytomas/paragangliomas...
متن کاملClinical management of pheochromocytoma and paraganglioma in Singapore: missed opportunities for genetic testing
BACKGROUND Pheochromocytomas and paragangliomas (PPGLs) are neuroendocrine tumors of the adrenal glands and paraganglia, occurring sporadically or as a range of hereditary tumor syndromes. About 30% of PPGLs are attributed to germline mutations. Clinical presentation, including localization, malignant potential, and age of onset, varies depending on the genetic background. Genetic testing for P...
متن کاملBiochemical Testing After Pheochromocytoma Removal: How Early?
Pheochromocytomas are catecholamine-producing tumors with typical clinical presentation. Tumor resection is considered as an appropriate treatment strategy. Due to its unpredictable clinical behavior, biochemical testing is mandatory to confirm the success of tumor removal after surgery. The aim of the study was to investigate the feasibility of a shorter interval of postoperative testing (earl...
متن کاملNovel Preclinical Testing Strategies for Treatment of Metastatic Pheochromocytoma
There is currently no effective treatment for metastatic pheochromocytomas and paragangliomas. A deficiency in currentchemotherapy regimens is that the metastases usually grow very slowly. Drugs that target dividing tumor cells havetherefore had limited success. To improve treatment, new strategies and valid experimental models are required for pre-clinical testing. However, develop...
متن کاملLow sensitivity of glucagon provocative testing for diagnosis of pheochromocytoma.
CONTEXT Pheochromocytomas can usually be confirmed or excluded using currently available biochemical tests of catecholamine excess. Follow-up tests are, nevertheless, often required to distinguish false-positive from true-positive results. The glucagon stimulation test represents one such test; its diagnostic utility is, however, unclear. OBJECTIVE The aim of the study was to determine the di...
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ژورنال
عنوان ژورنال: Current Hypertension Reports
سال: 2010
ISSN: 1522-6417,1534-3111
DOI: 10.1007/s11906-010-0151-1